Nanoparticles comprising an iron oxide core doped with radioisotope 223Ra and a coating layer of an organic compound, which may have application as radiotheranostic agents and in the treatment of cancer.
Compounds useful as reversible light-regulated agonists for activation of Vitamin D receptor (VDR) using wavelengths suitable for phototherapy, that would avoid the appearance of secondary effects, with application for the treatment of diseases that involve an alteration of the VDR function.
A recombinant gluten degrading protein that may have application as an agent or food additive for the prevention of gluten-mediated conditions, as well as in the food industry for the manufacturing of gluten-free products.
Nanoemulsions composed of an oil core and a surfactant coating, in combination with an antimicrobial peptide, which inhibit the formation of bacterial biofilms and can therefore be used for the treatment or prevention of diseases or contamination of surfaces.
New family of molecules (low-molecular weight peptides) present in olive oil with blood pressure-reducing activity for hypertensive people
Design of a novel proteolytic set of chimeras (26STACs) directed at the degradation of the ceramide transfer protein CERT-1 by the proteasome, in an E3-independent manner, for its use in the treatment of breast cancer.
Effective triple-negative breast cancer treatment based on the modulation of the phenotype of CD206+ tumor associated macrophages by means of a novel peptide-drug-conjugate (PDC) which is able to slow tumor progression and supress lung metastasis.
New tiourea- and urea-based glycolipids with immunomodulatory activity. The compounds are Mincle agonist and have shown in vitro and in vivo immunostimulant activity. They can be used as vacine adjuvants, in the modulation of the immune response and in the treatment of infectious disease or cancer.
Novel antiviral strategy targeting viral non-essential proteins (NEPs), scarcely prone to adaptive mutations. As a proof of concept, SARS-CoV-2 ORF9b homodimerization inhibitors have been identified that prevents the virus hyperinflammation response.
Andrographolide derivatives for its use as treatment for inflammatory diseases related to cytokine storm.