Liposomal lipid formulations for protection of oral mucosa permeation

Stratum corneum lipid-matrix like liposomes capable of acting as oral mucosa impermeabilization agents to prevent the penetration of viruses or biocides through the mucosa.

Market need: The barrier structure of the oral mucosa differs greatly from that of the skin, resulting in a increased permeability of different agents. The main difference in the penetration is due to the different lipid compositions as well as their packing structures.
Although there is a great deal of methods to enhance transmucosal permeation, there are scarce methods focused on its reduction for preventing contaminants uptake.

Proposed solution: Development of a series of liposomal formulations able to reduce permeation of biocides through the oral mucosa.
The reinforcement of the barrier function of mucosa by these formulations has been tested in vitro in a novel developed artificial mucosal membrane model and in a porcine sublingual membrane, showing in both cases a strong reduction of the permeation of different drugs and pesticides (over 80%). This effect can be extrapolated to toxic compounds such as viruses, contaminants, toxins, etc.

Competitive advantages

Formulations based on lipid combinations that are present in the stratum corneum, structured as liposomes.
These formulations reinforce the mucosa, increase its barrier effect and decrease its permeability to levels similar to those of the skin.
They may be used to prevent or reduce penetration of pathogens, such as viruses or toxins at the systemic level, through the mucosa.