Our group is dedicated to the study of the function of signaling through the mechanism of post-transductional modification of proteins known as poly ADP-ribosylation (PARylation), in regulating key aspects of the tumor microenvironment such as hypoxia and autophagy and how PARylation determines the malignant transformation of the tumor.

Our current research interest is in signal transduction and signaling molecules as drug targets or disease biomarkers. In our laboratory we have focused our interest on the early signaling events triggered by CD38 or CD3 engagement in T cells from patients and mice with autoimmune diseases.

(a) Signaling by TCR, BCR, and membrane receptors; by co-receptors CD38 and CD19; and by "Toll-like receptors “TLR2 and TLR4. Study the role of kinases, ERK-1 and 2; AKT1; Lck; Lyn; in the pathogenesis of Systemic Lupus Erythematosus (SLE); and Psoriasis. (b) Study the alterations in pro-inflammatory and regulatory cytokine involved in the regulation of the differentiation of helper T cell (Th1, Th2, Th17 and Treg) in plasma and gene expression levels in peripheral blood mononuclear cells (PBMC) from patients with SLE and Psoriasis.

The functional coupling of transcription and alternative splicing is emerging as an essential component of gene expression regulation. Despite considerable efforts, numerous questions remain regarding the functional significance and global impact of this coupling on cellular and organism homeostasis as well as its underlying molecular mechanisms. Our work considers that coupling mechanisms enable the establishment of check-points or quality controls that would promote each step of pre-mRNA synthesis and processing while ensuring the accomplishment of the essential preceding stages.

It has available a well equipped laboratory of 80m2. Enjoy a 2013-2015 National Plan Project and Project Explora (2012-2013) as IP, and is Participant in a Project Excellence Andalucía.IP Jordi Gómez is also IP of a group of CIBER liver and digestive diseases. A postdoctral and two predoctral memebers are currently beign founded. The group has regular contacts and exchange of samples with clinical researchers memebers in the area of viral hepatitis from several Hospitals (vall d’Hebron, Hospital Clinic Barcelona, etc..) and a group of tropical virus in the INIA.

Since its formation the Group has a multidisciplinary nature, oriented to the molecular and immunological characterization of functional genes and antigens that play an important role in the biology of various infectious agents of a protozoan type. At the beginning, the research activity of the group was eminently oriented to the generation of knowledge, and quickly it has been integrated into relevant studies of a applied research nature, both in the field of biotechnology and health.

The main goal of the Glycosystems Laboratory is the study in detail of the biologically relevant recognition processes involving carbohydrates, with the aim to intervene on these processes. In particular, the Glycosystems laboratory is focused on the synthesis of carbohydrates, glycoconjugates, and carbohydrate multivalent systems, the study of these entities at the structural level using computational and Nuclear Magnetic Resonance (NMR) techniques, and the analysis of the interactions of these carbohydrate systems with their corresponding receptors.

The Research team focus the activity under the motto “Carbohydrates for Health and Wellness: Glycodrugs, Glycotransportes and Glycobiotics”.

Our research group is formed by three staff scientists, They perform an interdisciplinary and complementary research that touches the fields of Chemical Biology and Pharmacology, oriented to the study of the regulation of reproductive functions in mammals. Besides, one technician currently add to the group personnel, with the help, in some instances, of a technician of the IIQ staff.