Formation and Function of mRNA

The functional coupling of transcription and alternative splicing is emerging as an essential component of gene expression regulation. Despite considerable efforts, numerous questions remain regarding the functional significance and global impact of this coupling on cellular and organism homeostasis as well as its underlying molecular mechanisms. Our work considers that coupling mechanisms enable the establishment of check-points or quality controls that would promote each step of pre-mRNA synthesis and processing while ensuring the accomplishment of the essential preceding stages. Proteins acting at the interface of these processes would serve as checkpoint factors to regulate co-transcriptional splicing. In addition to study the molecular events that govern these interactions, we want to go further and provide new insights regarding the molecular mechanisms at work in pathological situations, such as neurological disorders and cancer.