GENOMIC INSTABILITY AND CONTROL OF TUMOR PROGRESSION

Our group is dedicated to the study of the function of signaling through the mechanism of post-transductional modification of proteins known as poly ADP-ribosylation (PARylation), in regulating key aspects of the tumor microenvironment such as hypoxia and autophagy and how PARylation determines the malignant transformation of the tumor. Our group has made key contributions concerning the impact of PARP on tumor development, either because of its involvement in response to DNA damage and as a regulator of gene transcription through its association with factors involved in tumor progression and metastasis such as NF-kB, HIF-1 and SNAI1. A primary objective is the identification of PARylated proteins during hypoxia and autophagy to perform a complete map of PARyloma in the tumor microenvironment. The study of the signaling by PARylation is gaining great relevance in the context of tumor biology to identify patients who may benefit from treatment with PARP inhibitors.