System based on an algorithm that allows for highly accurate diagnosis of breast cancer through the analysis of stochastic intracellular fluctuations of tumor cells, using images obtained through digital microscopy.
Two different vaccines prototypes have been developed based on RNA replicons from SARS-CoV-2 and MERS-CoV, encapsulated in Virus-Like Particles (VLPs), which can be used as a vaccines to generate immunity and protect against infections by these coronavirus.
A panel of high affinity nanobodies (Nb) binding to diverse SARS-CoV-2 RBD epitopes of spike protein, and a set of nanobody-derived neutralizing heavy chain antibodies (hcAbs) have been identified. They have potential as therapy against SRAS-CoV-2 for immunocompromised or non-responding to vaccines individuals.
New family of molecules with potent and selective antiviral activity in cellular models of infection by various coronaviruses such as SARS-CoV-2, MERS-CoV, hCoV-229E. They do not show cytotoxicity or activity against other viruses with RNA genome such as West Nile fever virus, dengue virus and vesicular stomatitis virus at relevant doses.
The modulation of specific endogenous hormonal flows in neural routes has been observed to allow the modulation of social interaction preferences, opening the door to new therapies against social avoidance disorders
New procedure for obtaining cell spheroids by ultrasound from cell suspensions for in vitro studies, of special interest in the study of tumors without the need to use in vivo models.
Immunochemical method for diagnosis of infections produced by Pseudomonas aeruginosa targeting the main signalling molecules of the pqs Quorum Sensing system. The immunoassay is fast and efficient, with low LOD and adaptable to point-of-care devices.
Early and accurate diagnosis and follow up of diseases related to cystine accumulation, such as cystinosis and cystinuria, based on a molecular network producing a signal measurable by fluorescence when certain substances bind to cysteine or cystine, allowing abnormal levels of cystine to be detected.
Novel small molecules as valuable agents for controlling bleeding after heparin treatment. Lead compound studied has shown high efficacy and is expected to overcome side effects produced by current antidotes used in clinics.