Biomechanics of the nucleus and epigenetics during cell migration
Biomechanics of the nucleus and epigenetics during cell migration
Cell migration is central to numerous biological functions in embryogenesis, tissue renewal and immunity. Migration of a cell though tissues requires its interaction with its matrix environment, and recently it has become clear that cell plasticity is critical for this motility through narrow spaces. For that, the cell needs to alter the physical properties of the nucleus, as the major and most rigid organelle in the cell body.