The purpose of our laboratory in the study of RNA-guided gene regulation focused on the function of small and long non-coding RNAs guiding novel nuclear events. We are performing a detailed analysis of nuclear RNA processes by studying the identity, localization, and functions of specific nuclear RNA molecules, nuclear RNA/proteins complexes and nuclear shuttling processes in Arabidopsis thaliana and Caenorhabditis elegans. Through these analyses, we expect to characterize novel nuclear RNA pathways and to uncover their biological relevance.

Our laboratory is interested in understanding the cellular and molecular immunological mechanisms of autoimmunity and cancer. Specifically, we focus on studying how microRNAs (miRNAs) and their target genes regulate immune tolerance, autoimmune diseases and antitumor immunity. In addition, we are developing innovative genome engineering strategies for therapeutic purposes.

The goal of the lab is to examine novel levels of regulation of the proteasome pathway focusing on the mechanisms that control proteasome function and its interaction with protein substrates. Our ongoing studies pursue basic and applied research areas. Our objective is to characterize the regulatory interactions that control the proteasome and the impact cellular homeostasis. We also aim to identify novel ubiquitin pathway substrates by means of Omics approaches.

The group has a multidisciplinary approach with a strong background in microbiology and quality of fruit and vegetables, from an overall quality perspective. Several aspects of microbial and chemical food safety, fresh produce self-life, physiological characteristics, and organoleptic quality are included. The research topics deal with fundamental and applied aspects of pre-harvest and post-harvest factors affecting the quality and safety of fruit and vegetables.

Eco-evolutionary processes affecting plant–herbivore interactions. Predict how the future global change will influence plant-herbivore interactions. Management strategies of agroforestry systems

Theory, Bioinformatics and Computation (formerly Dynamics of Living Systems) is a research group created in the new research institute I2SysBio (2017), which includes physicists, biologists and computer engineers with research interests in systems biology. Our team develops basic and applied research in the area of Systems Biology, with emphasis in theoretical models, bioinformatics and computational studies of complex biological systems with interest in biomedicine and biotechnology.

The main interest of our group is to uncover the role of distal enhancers in the deployment of developmental gene expression programs as well as in the etiology of human congenital disorders.

The activity of this group is focused, through an agroecological and multidisciplinary approach, to optimize the integrated management of crop pests and diseases, deepening the study of compatible and incompatible interactions of plants with pests and plant-parasitic organisms (with special interest in the different types of plant resistance and the biotic and abiotic factors that affect them) and contributing to conservation of beneficial insects.