Our main goal is to explore the origins of the complexity on the biologic systems, searching for possible underlying universal laws in the emergence of structures in nature . To do this, we use complex networks, statistical physics, computational theory and , more recently , synthetic biology .

Our group focuses on patho-physiological aspects of cardiac excitation-contraction coupling and arrhythmogenesis. Our goal is to improve the understanding of key genetic and molecular factors underlying the development of pathological changes in cardiac contraction and rhythm We use quantitative electrophysiological techniques such as current- and voltage-clamp techniques as well as confocal imaging techniques in situ and in vitro (live-cell imaging to visualize changes in calcium or membrane potential and immunofluorescent labeling to visualize the distribution of proteins regulating intracel

This research group has got consolidated expertise in the study of the effects of minerals on metabolism, validation of the efficacy of functional foods in humans, and in nutrigenomics related to mineral metabolism. In this multidisciplinary field of the connection between minerals with other factors, the relationships between mineral and lipid metabolism, cardiometabolic risk, insulin sensitivity, and mineral and vitamin deficiencies are included.

The goal of our group is to discover new therapeutic strategies to combat the underlying alterations of the cognitive loss in pathological brain aging. The research aims to enable or enhance endogenous neuroprotective mechanisms in experimental systems of aging and Alzheimer disease (AD). We mainly focus in the involvement of epigenetic changes against neuroinflammation-linked neurodegeneration. The group uses animal models, cell cultures and samples of human tissue to investigate neuroprotection and prevention therapies.

The research group has its roots in the Protein Interactions and Docking group, founded in 2005 by the principal investigator, Juan Fernández Recio, at the Institut de Recerca Biomédica (IRB) of Barcelona, then relocated to the Barcelona Supercomputing Center (BSC) in 2007, and consolidated in 2017, when the PI joined the Institute of Molecular Biology of Barcelona (CSIC) as tenured scientist.

Our research group is interested in uncovering the molecular mechanisms regulating tissue homeostasis during normal development and during pathological conditions, in particular in cancer. Using a combination of novel transcriptome-wide analyses and mouse and human in vitro and in vivo models, we are focused on studying the role of post-transcriptional modifications such as RNA methylation in normal development and during pathological conditions. RNA modifications are beginning to define a novel layer of biological complexity that is becoming widely appreciated as the epitranscriptome.

MS4N group explore the use of diverse types of chemical multivalent platforms (oligomers, dendrimers, polymers, micelles and lipid nanovesicles), in: -the generation of multivalent ligands to study G protein-coupled receptor (GPCR) oligomerization; and -the development of drug delivery systems for advanced colorectal and triple negative breast cancer treatment, protein delivery systems for the treatment of lysosomal diseases and macromolecular compounds with intrinsically therapeutic properties with application to central nervous system diseases. The group also explore the use of different ta

The IPP research group "Citizens and Institutions" is a consolidated team, with a top-level international research trajectory. The group's mission is to generate knowledge about the social and political mechanisms that explain the relationship between institutions and citizenship in Spain, within the context of the institutions of the European Union, as well as in the broader scope of democratic societies.

Our group is interested in understanding how macromolecular machines control essential cellular functions. We rely on a blend of cryo-electron microscopy, x-ray crystallography, with biochemical and functional assays to help to understand these processes at atomic level.

The Group studies the biosynthesis of lipids and fatty acids in plants and seeds, and their role in acclimation responses (temperature) or in certain environmental stresses. Some fatty acids, such as linolenic acid (18:3), are precursors of jasmonic synthesis and, therefore, participate in the responses of the plant against pathogen attack. We study the role of omega-3 desaturases in this regulation and the interaction of the biosynthesis of poliunsaturated fatty acids with other stress signaling pathways in the plant, through the identification of specific transcription factors.