Regulation of the proteasome: control of cellular homeostasis and design of novel therapeutical approaches.

The goal of the lab is to examine novel levels of regulation of the proteasome pathway focusing on the mechanisms that control proteasome function and its interaction with protein substrates. Our ongoing studies pursue basic and applied research areas. Our objective is to characterize the regulatory interactions that control the proteasome and the impact cellular homeostasis. We also aim to identify novel ubiquitin pathway substrates by means of Omics approaches. The development of these projects will uncover mechanisms of action of the proteasome, which will be integrated in the comprehension of the role of the proteasome in cell physiology and molecular pathology. One of our priorities will be to reveal novel targets in the proteasome pathway for the design of drug therapies, by means of a novel generation of Protacs. The use of S. cerevisiae, the reference model in the ubiquitin-proteasome system, will allow us to address simultaneously biochemical, genetic and molecular approaches.