RNA virus dynamics in infected patients. New antiviral designs

Virus variability is one of the main obstacles for the effective prevention and treatment of viral diseases. The main objective of our laboratory is to understand viral dynamics of RNA viruses, based on deep sequencing data of in vivo and ex vivo viral populations. We aim at designing new antiviral strategies capable of counteracting virus adaptability which is responsible of treatment and vaccination failures. We are currently analyzing SARS-CoV-2 from nasopharyngeal swabs of the several pandemic waves, in the search of synergistic antiviral combinations to suppress viral replication, including the use of nucleoside analogues that act as lethal mutagens.