Multi-omic approaches and the role of sex in complex diseases

The research line focuses on identifying the genetic and molecular basis of complex diseases, with a particular emphasis on the role of sex in their etiopathogenesis. To achieve this, the approach integrates genome-wide association studies (GWAS), admixture mapping, high-throughput sequencing, and several computational methods, including functional genomics, epigenomics, and transcriptomics, both at the tissue and single-cell levels. These tools enable the unraveling of the underlying biology of these diseases, significantly contributing to the advancement of the scientific knowledge and its application for the development of precision medicine.