Molecular signaling and chromatin function

Our group is focused on understanding the role of epigenetic regulators in gene transcription during development, in particular during early neurogenesis. We are working to find out the contribution of histone methylation on chromatin homeostasis and activity and how its alteration leads to disease. To do that, we are using neural stem cells and chicken spinal cord as in vitro and in vivo models respectively. Our work will help to understand the molecular basis that regulate the genome activity during the development and to show how they are altered in pathological processes, helping to identify new therapeutic targets.