Laboratorio Cajal de Circuitos Corticales:Microorganization of the normal cerebral cortex and alterations of cortical circuits

Javier DeFelipe’s laboratory has an extensive experience in the analysis on the microorganization of the cerebral cortex using various techniques (intracellular injections, histochemical and immunocytochemical techniques for light and electron microscopy, 3D reconstruction methods). In 1991, he began studies of normal human cerebral cortex and epileptic patients. In parallel, since 2006, he progressed on the study of Alzheimer's disease. In 2009, he started the participation in the Blue Brain project. The laboratory's contribution to this project consist in developing microanatomical studies of the neocortical column, and coordinating research works carried out in other laboratories. This project has provided the basis for proposing the Human Brain Project (HBP, 2013) which is a much more ambitious project, with the participation of a greater number of laboratories. Javier DeFelipe is the co-director of the “Molecular and Cellular Neuroscience Division”.