IMMUNOREGULATION OF INFECTIOUS, INFLAMMATORY AND NEURODEGENERATIVE DISORDERS

To know the relationship between the central nervous system and the immune system, characterizing the connection between infectious diseases and their effects on neurodegenerative disorders, and on pathological aging processes. We are looking for endogenous mediators shared by both systems (neuropeptides) with a therapeutic profile in these disorders and/or that are relevant in the development and evolution of neuroinflammatory/neurodegenerative disorders (multiple sclerosis, Alzheimer's disease, Parkinson's disease, cerebral stroke). On the other hand, we have recently described additional functions of these neuropeptides as antimicrobial peptides, with which they have important aspects in common. We are studying the possible relationship between these antimicrobial neuropeptides and the protective effect during aging and against diseases of the central nervous system. We are also interested in cerebrovascular alterations associated with immune processes and dementia.