Chormosome Instability and Tumorigenesis

Gastric cancer (GC) is still the fourth main cause of cancer related death all over the world. Its high prevalence and the lack of efficient personalized treatments make it a mayor cause of public health concern. In GC, adenocarcinomas gastrectomy is the only curative treatment currently available, and it is frequently combined with adjuvant radio/chemotherapy. Thus, despite of recent improvements in care, there is still an imperative need to improve GC available treatments. Given the lack of good biomarkers for therapy response and patient prognosis, our focus of interest is to gain insight into the molecular pathways that condition the response to specific therapies in GC cell models. During the last years we have been analysing the correlation between Chromosomal Instability (CIN) and response to therapy in GC. The main area of interest of our laboratory is the study of biomarkers, which can help us predict the response to specific chemotherapy treatment regimes.