Cancer Genetics and Cancer Stem Cells

Adult stem cells, or tissue-specific stem cells maintain the tissue homostasis during the organism's life. We aim to understand the biology of these cells and their relationship with cancer stem cells (CSC). Using different celular models including mammary gland, mesenchymal stem cells, neuronal cells and immune cells we hace demonstrated the plasticity of the stem cells and their relationship with the CSC. The last years we have analyzxed the effect of monoclonal antibodies against meural stem cells and early progenitos in tissue regeneration and the treatment of glioblastomas. Fuethermore we have analyzed the effect of monoclonal antibodies against CCR9 for the treatment of human leukemia in xenotransplanted models