Alzheimers Disease Neurovascular Research Laboratory (LINEAlz)

Alzheimer¿s disease is a multifactorial neurodegenerative disorder and the most common form of dementia. This disorder was first reported by the German physician Alois Alzheimer in 1906 in a 51-year-old patient, named Auguste Deter, who had progressive cognitive and psychosocial impairment accompanied by aphasia, disorientation, hallucinations and delusions. At necropsy, Alois Alzheimer found that Auguste Deter’s brain presented cerebral atrophy, senile plaques, neurofibrillary degeneration and arteriosclerosis of the small cerebral vessels. More than a century has passed since that moment and the scientific community has made important progress on comprehending the neuropathological hallmarks of AD, i.e. amyloid plaques and neurofibrillary tangles. However, the disease still has no cure and the pharmacological approaches developed so far have had very limited success on delaying disease progression. The reason behind this failure may partly rely on the complexity of this neurode