Study of the structure and reactivity of molecules using the methods of theoretical and computational chemistry. We focus on two main areas: a) Oxidation reactions and chemistry of radicals, with play an important role in atmospheric chemistry, environmental chemistry and biological processes; and b) Study of protein dynamics, with a focus on intrinsically disordered proteins and enzyme catalysis.

The research group has worked during 14 years on natural products synthesis with biomedical application. The main objective of the group is the preparation by chemical synthesis of bioactive compounds based on natural products and study their biomedical application.

Our research is focused on the field of structural biology and particularly in the analysis of proteins and nucleic acids and theirs complexes using crystallography and other structural techniques such as small-angle X-ray scattering and electron microscopy. The group has a wide experience in the field and is a pioneer in the determination of the tridimensional structure of macromolecules in Spain. The group is also ascribed to the Institute fro Research ib Biomedicine (IRB Barcelona) and has been granted the category of consolidated research group by the Government of Catalonia.

Sphingolipids are relatively minor components of cell membranes, but the last two decades have witnessed an increased interest in these molecules, and particularly the simplest of them ceramide and sphingosine, due to (a) their proposed role in cell signalling, and (b) their unusual biophysical properties. The latter include the tendency of ceramides to form non-lamellar structures, to permeabilize bilayers, and to promote transbilayer (flip-flop) motion of lipids. These properties were discovered in our lab.

Functional proteomics aspires to draw a complete map of protein dynamics, interactions and posttranslational modifications that take place in the cell. Our goals within the CNB Functional Proteomics Group is to develop and apply state of the art tools to monitor proteins involved in molecular interactions and pathways relevant to pathologies in a variety of tissues, cell types and organisms upon various experimental treatments/conditions.

We are interested in understanding how cell division is controlled, and more specifically how before and during mitosis a number of signaling modules reorganize cellular elements with the objective of building the spindle and correctly segregating the duplicated chromosomes into two daughter cells (evidently quite an important process -think cell death, disease and mayhem in general if things go wrong with it).

Throughout its trajectory, the group has combined basic and applied research with the aim of improving the quality and safety of foods, mainly dairy products. To this end, two complementary lines of research are addressed: 1. Study of the functionality of starter and protective lactic acid bacteria to foster a sustainable dairy food chain providing optimized starters with improved technological traits that prevent failed fermentations. 2. Development of appropriate antimicrobials to ensure the quality and safety of food throughout the production chain (biopreservatives).

Transdiciplinary group (with expertise in theoretical biophysics, statistical physics, organic chemistry, supramolecular chemistry, computer simulation, theoretical biology, philosophy of science) investigating the origin of biological organization, its metabolic nature and the role of membrane compartments and organic interfaces in that organization.

Details of the group can be found in (http://in.umh.es/grupos-detalle.aspx?grupo=20) (http://painchannels.com/index.php/index). We are interested in the structure and function of ion channels, in particular understanding their role in sensing external stimuli, focusing on the role played in mammalian thermo and mechanosensation in physiological and neurophatic condition.

Group in transformation due to retirement of the previous IP. Our research is focused on the study of the cellular and molecular aspects of neurodegenerative diseases with an inflammatory component. At present, the main research line is the study of GRP78-CB1R interaction and neuroprotection. Group members also participate in research projects led by PIs from other IIBB groups.