UNCONVENTIONAL AUTOPHAGY IN HEALTH AND DISEASE

The laboratory's research focuses on understanding the role of autophagy, a cellular degradation process, in various biological contexts. Autophagy plays a crucial role in maintaining cellular homeostasis and protecting against diseases like cancer, inflammation, and neurodegenerative disorders. The lab specifically investigates the functions of different components of the autophagic machinery, such as ATG16L1, which have both canonical and unconventional roles. The lab aims to uncover these unconventional functions and their implications in areas like cell signaling, immune response, and disease progression. Through genetic manipulation, proteomics, and bioinformatics, they seek to shed light on the complex mechanisms of autophagy and its potential therapeutic applications.