REGULATORY FUNCTIONS AND MECHANISMS OF CELL SIGNALING PATHWAYS THROUGH G PROTEINS: A NEW INTERACTOME

Our laboratory is investigating the regulatory functions and mechanisms of cell signaling pathways through G proteins, particularly focusing on Gq protein-coupled receptors (GPCRs). We aim to understand how these pathways are involved in both normal physiological processes and pathological conditions. Our recent research has unveiled a new interaction region in Gαq, a subunit of G proteins, which plays a role in non-canonical Gq signaling and cell homeostasis. We are also studying the impact of Gαq on various cellular processes, such as autophagy, inflammation, and cancer progression, and exploring its modulation by accessory proteins. Additionally, we collaborate with other groups to study the role of GRK2 in skin immune responses and inflammatory diseases.