Molecular Pathology / Complement Genetics

Our objective is to characterize the molecular bases of human disease, focussing most recently in diseases related to the complement system. Our activities involve gene identification, mutation detection and biochemical, cellular and structural analysis of the proteins encoded by the disease-associated genes. A major objective is generating in vitro and in vivo models to increase our understanding of pathogenic mechanisms, to improve diagnostics and to develop preventive and therapeutic strategies.