Molecular Biology of Gametogenesis

The complex control of terminal cell differentiation producing gametes is mediated by regulation of gene expression interacting with multiple endocrine, paracrine and autocrine factors. Our laboratory is focused on the characterization of molecular mechanisms, through gene expression of both mRNAs and sRNAs (small RNAs), wich control and regulate the differentiation and development of oocytes and spermatozoa as well as the early embryos. Our currently study the role and regulation of genes involved in gametogenesis in both sexes and their contribution to zygotic preimplantation development. We also assess how their deregulation may be potentially responsible for impaired fertility induced by exposure to environmental pollutants including those considered as “endocrine disruptors”. With this, we aim to contribute to the proposals and challenges of Global Health in a key area such as Reproductive Health.