PRE2023-Molecular mechanisms of T lymphocyte activation and T-B cell cooperation during the humoral response-PID2022-136745OB-I00

A 4-year predoctoral contract* to join the laboratory of Prof. Balbino Alarcón at the Center for Molecular Biology (CBMSO) in Madrid, Spain aimed at investigating the earliest events in signal transduction by the T cell antigen receptor (TCR) and strategies to modulate its signaling in order to selectively inhibit T cell involvement in autoimmune diseases such as psoriasis, multiple sclerosis, rheumatoid arthritis or diabetes, while allowing the formation of a robust immune response against viral and microbial pathogens. In addition, the project aims at studying the molecular mechanisms of T cell help to B cell during the maturation of the humoral response that allows the generation of high affinity mature immunoglobulins of diagnostic and therapeutical interest. The laboratory has also an interest on exploring the relevance of the RAS-related GTPase R-RAS2 in human cancer.