Inflammation and lipid metabolism

Our main research goal is to study lipid-modifiying enzymes in the immune system. Lipins are phosphatidic acid fosfatases that generate diacylglycerol, a signalling lipid that is involved in signal transduction during cellular immune activation. Althought mutations in human lpin genes promote inflammation-related disseases, very little is known about the role of lipin in inmune cells or the development of inflammatory processes. Our main goal is to answer these questions.